Osteosclerosis in myeloma.

In multiple myeloma the typical bone lesions are usually purely osteolytic and the presence of any osteosclerosis suggests that the diagnosis should be reconsidered. There have now been reports of forty-nine patients with myeloma with osteosclerotic deposits in whom radiotherapy could not be implicated as a cause (Kr , Wiedermann, Vykydal and Soyka 1967; Evison and Evans 1967; Osuntokun, Akinkugbe and McFarlane 1969; Mopkar and Patel 1970; Talerman and Bateson 1970). We describe a further patient with osteosclerotic myeloma whose case is very unusual in that a large part of the skeleton was affected.